Evaluation of nutritional and sub-acute toxicological study of plant based supplement of Achyranthes aspera

The present study was conducted for the nutritional, microbiological and toxicological evaluation of test compound having main ingredient Achyranthes aspera

Nutritional value assessment, microbiological analysis and toxicological studies were conducted according to the standard reported methods which exhibited that A. aspera contains moisture 4.05%, proteins 20.54%, fats 0.903%, ash 20.25%, carbohydrates 54,26% and energy 294 Kcal. Vitamin profile was found to be B1 0.27mg/100g, B[2] 0.28mg/100g, B[3] 0.58mg/100g, B[6] 0.27mg/100g and B[9] 39microg/100g. The content of sodium, calcium, magnesium, potassium, chloride and phosphorus was found to be 1119.67, 5385.23, 5446.08, 1343.6, 675880.73 and 1447.5mg/kg respectively and trace metals i.e. iron, copper, zinc, manganese and aluminum were detected as 283.05, 8.062, 48.37, 16.12 and 9.853 mg/kg respectively

The microbiological result indicated that the compound qualifies the international standards of microbial limit and was found free from Salmonella species

The toxicological study was conducted to find safe use of Achyranthes aspera compound in human as a nutritive supplement in blood disorders

The toxicity studies exhibited that the test compound has a good effect on general health as an increase in body weights of animals of test group was noticed as compared to that of control group. Blood parameters before and after the study were monitored which confirms our hypothesis by showing an increase in hemoglobin from 9.133 to 10.96, RBC count from 3.11 to 3.6, WBC count from 5.68 to 5.73 and platelets from 245 to 319

large unilocular mucinous cystadenoma in third trimester of pregnancy

Ovarian malignancy is the second most common gynaecological malignancy diagnosed during pregnancy. A grand multipara, aged 30 years presented with gestational amenorrhea with abdominal discomfort and breathlessness for last 15 days. Sonographic examination demonstrated a huge, unilocular ovarian cyst and an alive fetus of about 30 weeks gestation. Intraoperative findings were huge left ovarian cyst [42x40x20 cm] with straw coloured mucinous fluid. Left salpingo-oophorectomy was performed followed by peritoneal washings and omental biopsy. Histopathology revealed mucinous cystadenomas with inflammatory changes in omentum and no malignant cells in peritoneal washings. She delivered vaginally a female baby of 3.5 kg at 38 weeks with good Apgar score

Oral misoprostol for induction of labour

To determine the effect of oral Misoprostol in labour induction with respect to ease of administration and induction-to-delivery time interval. Observational study. Gynaecology/Obstetrics Department, Holy Family Hospital, Rawalpindi, from March to August 2006. Women with live singleton pregnancy of >37 weeks gestation with cephalic presentation, with an indication for induction of labour were inducted. Oral misoprostol 50 microg to 400 microg was given in divided doses at 4 hours interval upto a maximum of 4 doses, till labour was induced. Fetomaternal outcome and induction to delivering time interval in hours was noted. In 6 months duration, 250 mothers were recruited for the study. The main indication for labour induction was post date pregnancy [52%] and oxytocin was given in 50% cases. The majority [96%] of mothers went into labour but 4% [9] had failed induction. The majority [73%, n=176/241] of mothers delivered vaginally, 99% being delivered in the first 24 hours. Mean induction-delivery interval was 11 +/- 2.7 hours. Sixty five [27%] had to undergo emergency lower segment caesarean section, the major indication being fetal distress [41.5%, n=27] and meconium staining of liquor [40%, n=26]. Again, a majority [95%] of the babies were delivered with good Apgar score. However, 10.8% developed meconium aspiration syndrome. Early neonatal deaths occurred in 0.8% [2] cases. Maternal hyper stimulation was seen in 1 case [0.4%]. Oral misoprostol as an agent for labour induction in term pregnancy was easy to administer and the majority of women [99%] delivered in the first 24 hours